Endocrine Abstracts

Introduction: : Adrenocortical carcinoma (ACC) is a rare tumor, often with an unfavorable prognosis. The management of ACC is challenging due to its low frequency and limited experience. The objective of this study was to describe the adverse events (AE) in patients diagnosed with ACC treated in the Divisions of Endocrinology and Oncology at the Ramón y Cajal University Hospital (Madrid, Spain) in the last seven years.Methods: Records of patients wi...

Aim: To evaluate the prevalence and incidence of type 2 diabetes in patients with nonfunctioning adrenal incidentalomas (NFAI) and autonomous cortisol secretion (ACS) coming from a cohort of adrenal incidentalomas consecutively evaluated in a tertiary hospital in a predefined period (2013-2020).Methods: In this retrospective study, adrenal incidentalomas ≥1cm with ACS and NFAI were included. ACS was defined by a post-dexamethasone suppression test ...

Objective: To study the differences in the metabolic profile of patients with non-functioning adrenal adenomas (NFA) and autonomous cortisol secretion (ACS).Methods: 143 patients diagnosed of adrenal incidentaloma (AI) between 2010 and 2018 were retrospectively analyzed. AI was defined as an adrenal mass≥1 cm, accidentally discovered by radiologic examination. ACS was confirmed by serum cortisol post-dexamethasone suppression test (Nugent)≥3 ...

PurposeTo evaluate the prevalence of bilateral macronodular adrenal hyperplasia (BMAH) in patients with adrenal incidentalomas (AIs) and analyse the differential phenotype of patients with BMAH compared to other bilateral adrenal lesions which do not meet BMAH definition (non-BMAH), with associated possible or confirmed autonomous cortisol secretion (ACS).MethodsRetrospective study of patients with AIs diagno...

Objective: To investigate factors associated with the presence and growth rate of thyroid nodules(TN) in patients with acromegaly.Methods: We retrospectively evaluated the medical records of 52 patients with acromegaly followed in our institution (University Hospital Ramón y Cajal). The frequencies of TN and papillary thyroid cancer (PTC) and potential factors associated with nodular thyroid disease (NTD) were investigated. In patients with NTD (<em...

Introduction: Adrenal incidentalomas are tumors incidentally discovered on imaging tests. Regarding functionality, although 75% of adrenal incidentalomas are non-functioning cortical adenomas (NFAA), there is a subset of adrenal incidentalomas associated with important clinical consequences: adrenocortical cancer (ACC), pheochromocytoma (PHEO, together with paraganglioma (PGL) referred as PPGL), primary aldosteronism (PA), mild-autonomous cortisol secretion (MACS) and Cushing ...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Aim: Evaluate the predictive value of the Pituitary Apoplexy Score (PAS) for predicting hormonal and visual recovery after surgery or conservative management of patients with pituitary apoplexy (PA).Methods: Multicenter retrospective study of patients presenting with clinical PA in three Spanish tertiary hospitals between 2008 and 2022. The PAS was calculated following the UK Pituitary Apoplexy Guidelines Development Group evaluation grid.<p class="a...

A 68-year-old man with history of non-muscle-infiltrating bladder tumor and atrial fibrillation was referred to the Endocrinology Department in November 2020 for a functional study of a left adrenal incidentaloma. Furthermore, the patient had a history of arterial hypertension diagnosed at the age of 45 years, on treatment with 3 drugs (enalapril 20 mg B.I.D., amlodipine 5 mg B.I.D., hydrochlorothiazide 12.5 mg/day), achieving usual blood pressure (BP) levels of 150/90 mmHg. A...

Context: There is no data on mortality of acromegaly diagnosed in the elderly. Objective: To compare clinical characteristics, GH-related comorbidities, therapeutic approaches and mortality of patients diagnosed before or after 2010 and to assess overall mortality compared with the general Spanish population. Setting: Spanish tertiary care centers.Design, Patients, and Methods: Retrospective evaluation of 118...